diff --git a/pkgs/development/python-modules/karton-dashboard/default.nix b/pkgs/development/python-modules/karton-dashboard/default.nix
index 5b67123ee2788..89664f6da8e66 100644
--- a/pkgs/development/python-modules/karton-dashboard/default.nix
+++ b/pkgs/development/python-modules/karton-dashboard/default.nix
@@ -43,5 +43,6 @@ buildPythonPackage rec {
     homepage = "https://github.com/CERT-Polska/karton-dashboard";
     license = with licenses; [ bsd3 ];
     maintainers = with maintainers; [ fab ];
+    broken = versionAtLeast mistune.version "2";
   };
 }
diff --git a/pkgs/development/python-modules/lektor/default.nix b/pkgs/development/python-modules/lektor/default.nix
index 0c0c5c108a46a..fa8e12dfc9c66 100644
--- a/pkgs/development/python-modules/lektor/default.nix
+++ b/pkgs/development/python-modules/lektor/default.nix
@@ -79,5 +79,6 @@ buildPythonPackage rec {
     homepage = "https://www.getlektor.com/";
     license = licenses.bsd0;
     maintainers = with maintainers; [ costrouc ];
+    broken = true;
   };
 }
diff --git a/pkgs/development/python-modules/m2r/default.nix b/pkgs/development/python-modules/m2r/default.nix
index fd1483826177b..147d41e166b49 100644
--- a/pkgs/development/python-modules/m2r/default.nix
+++ b/pkgs/development/python-modules/m2r/default.nix
@@ -29,5 +29,6 @@ buildPythonPackage rec {
     description = "Markdown to reStructuredText converter";
     license = licenses.mit;
     maintainers = with maintainers; [ SuperSandro2000 ];
+    broken = versionAtLeast mistune.version "2";
   };
 }
diff --git a/pkgs/development/python-modules/mistune/default.nix b/pkgs/development/python-modules/mistune/default.nix
index 515844443f121..97787b1ba315c 100644
--- a/pkgs/development/python-modules/mistune/default.nix
+++ b/pkgs/development/python-modules/mistune/default.nix
@@ -11,5 +11,5 @@ self: rec {
     sha256 = "sha256-nuCmYFPiJnq6dyxx4GiR+o8a9tSwHV6E4me0Vw1NmAg=";
     format = "pyproject";
   };
-  mistune = mistune_0_8;
+  mistune = mistune_2_0;
 }
diff --git a/pkgs/development/python-modules/mrkd/default.nix b/pkgs/development/python-modules/mrkd/default.nix
index 22cd93910d6b9..a33c1639e7acd 100644
--- a/pkgs/development/python-modules/mrkd/default.nix
+++ b/pkgs/development/python-modules/mrkd/default.nix
@@ -24,5 +24,6 @@ buildPythonPackage rec {
     description = "Write man pages using Markdown, and convert them to Roff or HTML";
     homepage = "https://github.com/refi64/mrkd";
     license = licenses.bsd2;
+    broken = versionAtLeast mistune.version "2";
   };
 }
diff --git a/pkgs/development/python-modules/nbconvert/default.nix b/pkgs/development/python-modules/nbconvert/default.nix
index 9b85586f7d9be..a4b7e3c451f4f 100644
--- a/pkgs/development/python-modules/nbconvert/default.nix
+++ b/pkgs/development/python-modules/nbconvert/default.nix
@@ -3,12 +3,13 @@
 , buildPythonPackage
 , defusedxml
 , fetchPypi
+, fetchpatch
 , ipywidgets
 , jinja2
 , jupyterlab-pygments
 , lib
 , markupsafe
-, mistune
+, mistune_2_0
 , nbclient
 , pandocfilters
 , pyppeteer
@@ -18,22 +19,34 @@
 
 buildPythonPackage rec {
   pname = "nbconvert";
-  version = "6.5.0";
+  version = "6.5.3";
   format = "setuptools";
 
   src = fetchPypi {
     inherit pname version;
-    hash = "sha256-Ij5G4nq+hZa4rtVDAfrbukM7f/6oGWpo/Xsf9Qnu6Z0=";
+    hash = "sha256-EO1pPEz9PGNYPIfKXDovbth0FFEDWV84JO/Mjfy3Uiw=";
   };
 
   # Add $out/share/jupyter to the list of paths that are used to search for
   # various exporter templates
   patches = [
     ./templates.patch
+
+    # Use mistune 2.x
+    (fetchpatch {
+      name = "support-mistune-2.x.patch";
+      url = "https://github.com/jupyter/nbconvert/commit/e870d9a4a61432a65bee5466c5fa80c9ee28966e.patch";
+      hash = "sha256-kdOmE7BnkRy2lsNQ2OVrEXXZntJUPJ//b139kSsfKmI=";
+      excludes = [ "pyproject.toml" ];
+    })
   ];
 
   postPatch = ''
     substituteAllInPlace ./nbconvert/exporters/templateexporter.py
+
+    # Use mistune 2.x
+    substituteInPlace setup.py \
+        --replace "mistune>=0.8.1,<2" "mistune>=2.0.3,<3"
   '';
 
   propagatedBuildInputs = [
@@ -43,7 +56,7 @@ buildPythonPackage rec {
     jinja2
     jupyterlab-pygments
     markupsafe
-    mistune
+    mistune_2_0
     nbclient
     pandocfilters
     tinycss2
diff --git a/pkgs/development/python-modules/schema-salad/default.nix b/pkgs/development/python-modules/schema-salad/default.nix
index 995c7e206faf3..3bf2fc36a6960 100644
--- a/pkgs/development/python-modules/schema-salad/default.nix
+++ b/pkgs/development/python-modules/schema-salad/default.nix
@@ -53,5 +53,6 @@ buildPythonPackage rec {
     homepage = "https://github.com/common-workflow-language/schema_salad";
     license = with licenses; [ asl20 ];
     maintainers = with maintainers; [ veprbl ];
+    broken = true;
   };
 }