diff --git a/pkgs/development/python-modules/twisted/default.nix b/pkgs/development/python-modules/twisted/default.nix
index 59011ef1d640d..ceaadd74ee6e6 100644
--- a/pkgs/development/python-modules/twisted/default.nix
+++ b/pkgs/development/python-modules/twisted/default.nix
@@ -119,7 +119,8 @@ buildPythonPackage rec {
     pyhamcrest
   ]
   ++ passthru.optional-dependencies.conch
-  ++ passthru.optional-dependencies.tls;
+  # not supported on aarch64-darwin: https://github.com/pyca/pyopenssl/issues/873
+  ++ lib.optionals (!(stdenv.isDarwin && stdenv.isAarch64)) passthru.optional-dependencies.tls;
 
   checkPhase = ''
     export SOURCE_DATE_EPOCH=315532800