diff --git a/tensorrt_llm/_torch/model_config.py b/tensorrt_llm/_torch/model_config.py
index f2a15151d781..fa448d8876c2 100644
--- a/tensorrt_llm/_torch/model_config.py
+++ b/tensorrt_llm/_torch/model_config.py
@@ -1,4 +1,5 @@
 import contextlib
+import errno
 import json
 import os
 import tempfile
@@ -86,8 +87,14 @@ def config_file_lock(timeout: int = 10):
     try:
         with lock:
             yield
-    except (PermissionError, filelock.Timeout):
-        # Fallback to tempdir
+    except (PermissionError, OSError, filelock.Timeout) as e:
+        # Fallback to tempdir when primary lock path is unusable (e.g.,
+        # NFS locking failures like ENOLCK/ESTALE, permission issues,
+        # or lock acquisition timeouts)
+        if isinstance(e,
+                      OSError) and e.errno not in (errno.EACCES, errno.EPERM,
+                                                   errno.ENOLCK, errno.ESTALE):
+            raise
         tmp_dir = Path(tempfile.gettempdir())
         tmp_dir.mkdir(parents=True, exist_ok=True)
         tmp_lock_path = tmp_dir / "_remote_code.lock"
@@ -101,7 +108,11 @@ def config_file_lock(timeout: int = 10):
             )
             # proceed without lock
             yield
-        except (PermissionError) as e:
+        except (PermissionError, OSError) as e:
+            if isinstance(
+                    e, OSError) and e.errno not in (errno.EACCES, errno.EPERM,
+                                                    errno.ENOLCK, errno.ESTALE):
+                raise
             logger.warning(
                 f"tempdir config lock unavailable due to OS/permission issue: {e}, proceeding without lock"
             )