NAs produced by integer overflow

[ayyildizd]

Hi,

While running findCDImarkers function I had this error:

2024-03-26 13:26:58.175816: Computing co-dependency indices...
  |++++++++++++++++++++++++++++++++++                | 67% ~04s          Error in binom.test(x = imat[i, j], n = ncol(emat), p = fmat[i, j], alternative = "greater") : 
  'p' must be a single number between 0 and 1
In addition: There were 50 or more warnings (use warnings() to see the first 50)

when I check the warnings I get :

length(x) * length(y) : NAs produced by integer overflow

and I think it is due to this step here:

pmat <- mysapply(which.cells2, function(x) sapply(which.cells, 
    function(y) length(x) * length(y)))

and I fixed the error by taking integers with as.integer64() from the bit64 package to handle larger integer values.

pmat <- mysapply(which.cells2, function(x) sapply(which.cells, 
    function(y) as.integer64(length(x)) * as.integer64(length(y))))

However this inflated my FDR values. Could you help in this?