diff --git a/Marlin/src/HAL/HAL_STM32/HAL.cpp b/Marlin/src/HAL/HAL_STM32/HAL.cpp
index 1bddf77f48a4..8a5e76eb3d96 100644
--- a/Marlin/src/HAL/HAL_STM32/HAL.cpp
+++ b/Marlin/src/HAL/HAL_STM32/HAL.cpp
@@ -21,7 +21,8 @@
  *
  */
 
-#ifdef ARDUINO_ARCH_STM32
+#if defined(ARDUINO_ARCH_STM32) && !defined(STM32GENERIC)
+
 
 // --------------------------------------------------------------------------
 // Includes
diff --git a/Marlin/src/HAL/HAL_STM32/HAL_Servo_STM32.cpp b/Marlin/src/HAL/HAL_STM32/HAL_Servo_STM32.cpp
index 2b08ab31446d..bc6f154e8337 100644
--- a/Marlin/src/HAL/HAL_STM32/HAL_Servo_STM32.cpp
+++ b/Marlin/src/HAL/HAL_STM32/HAL_Servo_STM32.cpp
@@ -20,7 +20,8 @@
  * along with this program.  If not, see <http://www.gnu.org/licenses/>.
  *
  */
-#ifdef ARDUINO_ARCH_STM32
+#if defined(ARDUINO_ARCH_STM32) && !defined(STM32GENERIC)
+
 
 #include "../../inc/MarlinConfig.h"
 
diff --git a/Marlin/src/HAL/HAL_STM32/HAL_spi_STM32.cpp b/Marlin/src/HAL/HAL_STM32/HAL_spi_STM32.cpp
index 597305fa06a0..a11b1585f7fc 100644
--- a/Marlin/src/HAL/HAL_STM32/HAL_spi_STM32.cpp
+++ b/Marlin/src/HAL/HAL_STM32/HAL_spi_STM32.cpp
@@ -20,7 +20,8 @@
  * along with this program.  If not, see <http://www.gnu.org/licenses/>.
  *
  */
-#ifdef ARDUINO_ARCH_STM32
+#if defined(ARDUINO_ARCH_STM32) && !defined(STM32GENERIC)
+
 
 // --------------------------------------------------------------------------
 // Includes
diff --git a/Marlin/src/HAL/HAL_STM32/HAL_timers_STM32.cpp b/Marlin/src/HAL/HAL_STM32/HAL_timers_STM32.cpp
index 23a1e3bf15aa..cebec33dc721 100644
--- a/Marlin/src/HAL/HAL_STM32/HAL_timers_STM32.cpp
+++ b/Marlin/src/HAL/HAL_STM32/HAL_timers_STM32.cpp
@@ -19,7 +19,8 @@
  * along with this program.  If not, see <http://www.gnu.org/licenses/>.
  *
  */
-#ifdef ARDUINO_ARCH_STM32
+#if defined(ARDUINO_ARCH_STM32) && !defined(STM32GENERIC)
+
 
 // --------------------------------------------------------------------------
 // Includes
diff --git a/Marlin/src/HAL/HAL_STM32/fastio_STM32.cpp b/Marlin/src/HAL/HAL_STM32/fastio_STM32.cpp
index e1824ed181bb..ae429c89214f 100644
--- a/Marlin/src/HAL/HAL_STM32/fastio_STM32.cpp
+++ b/Marlin/src/HAL/HAL_STM32/fastio_STM32.cpp
@@ -20,7 +20,7 @@
  * along with this program.  If not, see <http://www.gnu.org/licenses/>.
  *
  */
-#ifdef ARDUINO_ARCH_STM32
+#if defined(ARDUINO_ARCH_STM32) && !defined(STM32GENERIC)
 
 #include "../../inc/MarlinConfig.h"
 
diff --git a/Marlin/src/HAL/HAL_STM32/persistent_store_impl.cpp b/Marlin/src/HAL/HAL_STM32/persistent_store_impl.cpp
index 5fc87cc241d1..a4c9850c755e 100644
--- a/Marlin/src/HAL/HAL_STM32/persistent_store_impl.cpp
+++ b/Marlin/src/HAL/HAL_STM32/persistent_store_impl.cpp
@@ -20,7 +20,7 @@
  * along with this program.  If not, see <http://www.gnu.org/licenses/>.
  *
  */
-#ifdef ARDUINO_ARCH_STM32
+#if defined(ARDUINO_ARCH_STM32) && !defined(STM32GENERIC)
 
 #include "../../inc/MarlinConfig.h"
 
diff --git a/Marlin/src/HAL/HAL_STM32/watchdog_STM32.cpp b/Marlin/src/HAL/HAL_STM32/watchdog_STM32.cpp
index 7b049f155122..304e0c47fb29 100644
--- a/Marlin/src/HAL/HAL_STM32/watchdog_STM32.cpp
+++ b/Marlin/src/HAL/HAL_STM32/watchdog_STM32.cpp
@@ -20,7 +20,7 @@
  *
  */
 
-#ifdef ARDUINO_ARCH_STM32
+#if defined(ARDUINO_ARCH_STM32) && !defined(STM32GENERIC)
 
 #include "../../inc/MarlinConfig.h"
 
diff --git a/Marlin/src/HAL/HAL_STM32F4/EEPROM_Emul/eeprom_emul.cpp b/Marlin/src/HAL/HAL_STM32F4/EEPROM_Emul/eeprom_emul.cpp
index c13d428187f1..8bae46777d3d 100644
--- a/Marlin/src/HAL/HAL_STM32F4/EEPROM_Emul/eeprom_emul.cpp
+++ b/Marlin/src/HAL/HAL_STM32F4/EEPROM_Emul/eeprom_emul.cpp
@@ -47,7 +47,7 @@
 /** @addtogroup EEPROM_Emulation
   * @{
   */
-#if defined(STM32GENERIC) && (defined(STM32F4) || defined(STM32F4xx))
+#if defined(STM32GENERIC) && (defined(STM32F4))
 
 /* Includes ------------------------------------------------------------------*/
 #include "eeprom_emul.h"
diff --git a/Marlin/src/HAL/HAL_STM32F4/EmulatedEeprom.cpp b/Marlin/src/HAL/HAL_STM32F4/EmulatedEeprom.cpp
index 7d45ef18d06b..dfb005dc2b58 100644
--- a/Marlin/src/HAL/HAL_STM32F4/EmulatedEeprom.cpp
+++ b/Marlin/src/HAL/HAL_STM32F4/EmulatedEeprom.cpp
@@ -17,7 +17,7 @@
  *
  */
 
-#if defined(STM32GENERIC) && (defined(STM32F4) || defined(STM32F4xx))
+#if defined(STM32GENERIC) && (defined(STM32F4))
 
 /**
  * Description: functions for I2C connected external EEPROM.
@@ -139,4 +139,4 @@ void eeprom_update_block(const void *__src, void *__dst, size_t __n) {
 }
 
 #endif // ENABLED(EEPROM_SETTINGS) && DISABLED(I2C_EEPROM) && DISABLED(SPI_EEPROM)
-#endif // STM32F4 || STM32F4xx
+#endif // STM32GENERIC && STM32F4
diff --git a/Marlin/src/HAL/HAL_STM32F4/HAL.cpp b/Marlin/src/HAL/HAL_STM32F4/HAL.cpp
index 56823ccc8357..8b107f391b48 100644
--- a/Marlin/src/HAL/HAL_STM32F4/HAL.cpp
+++ b/Marlin/src/HAL/HAL_STM32F4/HAL.cpp
@@ -21,7 +21,7 @@
  *
  */
 
-#if defined(STM32GENERIC) && (defined(STM32F4) || defined(STM32F4xx))
+#if defined(STM32GENERIC) && defined(STM32F4)
 
 // --------------------------------------------------------------------------
 // Includes
@@ -130,4 +130,4 @@ uint16_t HAL_adc_get_result(void) {
   return HAL_adc_result;
 }
 
-#endif // STM32F4 || STM32F4xx
+#endif // // STM32GENERIC && STM32F4
diff --git a/Marlin/src/HAL/HAL_STM32F4/HAL_Servo_STM32F4.cpp b/Marlin/src/HAL/HAL_STM32F4/HAL_Servo_STM32F4.cpp
index 9d9c722e58e2..8c7adeecb5a7 100644
--- a/Marlin/src/HAL/HAL_STM32F4/HAL_Servo_STM32F4.cpp
+++ b/Marlin/src/HAL/HAL_STM32F4/HAL_Servo_STM32F4.cpp
@@ -21,7 +21,7 @@
  *
  */
 
-#if defined(STM32GENERIC) && (defined(STM32F4) || defined(STM32F4xx))
+#if defined(STM32GENERIC) && defined(STM32F4)
 
 #include "../../inc/MarlinConfig.h"
 
@@ -50,4 +50,4 @@ void libServo::move(const int value) {
 }
 #endif // HAS_SERVOS
 
-#endif // STM32F4 || STM32F4xx
+#endif // STM32GENERIC && STM32F4
diff --git a/Marlin/src/HAL/HAL_STM32F4/HAL_spi_STM32F4.cpp b/Marlin/src/HAL/HAL_STM32F4/HAL_spi_STM32F4.cpp
index 34582c30ade6..a7e840fb0377 100644
--- a/Marlin/src/HAL/HAL_STM32F4/HAL_spi_STM32F4.cpp
+++ b/Marlin/src/HAL/HAL_STM32F4/HAL_spi_STM32F4.cpp
@@ -30,7 +30,7 @@
  * Adapted to the STM32F4 HAL
  */
 
-#if defined(STM32GENERIC) && (defined(STM32F4) || defined(STM32F4xx))
+#if defined(STM32GENERIC) && defined(STM32F4)
 
 // --------------------------------------------------------------------------
 // Includes
@@ -173,4 +173,4 @@ void spiSendBlock(uint8_t token, const uint8_t* buf) {
 
 #endif // SOFTWARE_SPI
 
-#endif // STM32F4 || STM32F4xx
+#endif // STM32GENERIC && STM32F4
diff --git a/Marlin/src/HAL/HAL_STM32F4/HAL_timers_STM32F4.cpp b/Marlin/src/HAL/HAL_STM32F4/HAL_timers_STM32F4.cpp
index 6a23090a24ca..acf58858a9d9 100644
--- a/Marlin/src/HAL/HAL_STM32F4/HAL_timers_STM32F4.cpp
+++ b/Marlin/src/HAL/HAL_STM32F4/HAL_timers_STM32F4.cpp
@@ -20,7 +20,7 @@
  *
  */
 
-#if defined(STM32GENERIC) && (defined(STM32F4) || defined(STM32F4xx))
+#if defined(STM32GENERIC) && defined(STM32F4)
 
 // --------------------------------------------------------------------------
 // Includes
@@ -156,4 +156,4 @@ bool HAL_timer_interrupt_enabled(const uint8_t timer_num) {
   return false;
 }
 
-#endif // STM32F4 || STM32F4xx
+#endif // STM32GENERIC && STM32F4
diff --git a/Marlin/src/HAL/HAL_STM32F4/persistent_store_eeprom.cpp b/Marlin/src/HAL/HAL_STM32F4/persistent_store_eeprom.cpp
index ef70389714f4..48b6492c1189 100644
--- a/Marlin/src/HAL/HAL_STM32F4/persistent_store_eeprom.cpp
+++ b/Marlin/src/HAL/HAL_STM32F4/persistent_store_eeprom.cpp
@@ -21,7 +21,7 @@
  *
  */
 
-#if defined(STM32GENERIC) && (defined(STM32F4) || defined(STM32F4xx))
+#if defined(STM32GENERIC) && defined(STM32F4)
 
 #include "../shared/persistent_store_api.h"
 
@@ -66,4 +66,4 @@ bool PersistentStore::read_data(int &pos, uint8_t* value, size_t size, uint16_t
 size_t PersistentStore::capacity() { return E2END + 1; }
 
 #endif // EEPROM_SETTINGS
-#endif // STM32F4 || STM32F4xx
+#endif // STM32GENERIC && STM32F4
diff --git a/Marlin/src/HAL/HAL_STM32F4/watchdog_STM32F4.cpp b/Marlin/src/HAL/HAL_STM32F4/watchdog_STM32F4.cpp
index dd4d4391c620..41c75e411dae 100644
--- a/Marlin/src/HAL/HAL_STM32F4/watchdog_STM32F4.cpp
+++ b/Marlin/src/HAL/HAL_STM32F4/watchdog_STM32F4.cpp
@@ -20,7 +20,7 @@
  *
  */
 
-#if defined(STM32GENERIC) && (defined(STM32F4) || defined(STM32F4xx))
+#if defined(STM32GENERIC) && defined(STM32F4)
 
 #include "../../inc/MarlinConfig.h"
 
@@ -54,4 +54,4 @@
 
 #endif // USE_WATCHDOG
 
-#endif // STM32F4 || STM32F4xx
+#endif // STM32GENERIC && STM32F4