The Common Fund Data Ecosystem (CFDE) aims to facilitate better integration, and reuse of Common Fund data to accelerate discoveries in biomedical research.The Data Distillery project aims to integrate summarized (“distilled”) Common Fund data within a knowledge graph. The purpose of the Data Distillery Knowledge Graph (DDKG) is to link multiple sources of expertly curated data, thus providing data integration across multiple Common Fund data coordinating centers (DCCs). The summarized data are provided by participating DCCs and funded as part of the Common Fund Data Ecosystem (CFDE) project. The DDKG schema is based on the Unified Biomedical Knowledge Graph (UBKG) which originates from the Unifield Medical Language System (UMLS). The UBKG supports the DDKG with over 180 different ontologies and standards supporting the Common Fund data that either are native to UMLS or were explicitly added to support biomolecular data. The DDKG can be used to create simple to complex queries, and use the results for a range of different applications related to the use of Common Fund data.