diff --git a/var/spack/repos/builtin/packages/crtm-fix/package.py b/var/spack/repos/builtin/packages/crtm-fix/package.py
index 7c30f6aebd34dd..2499c2e047fb2a 100644
--- a/var/spack/repos/builtin/packages/crtm-fix/package.py
+++ b/var/spack/repos/builtin/packages/crtm-fix/package.py
@@ -58,23 +58,27 @@ def install(self, spec, prefix):
         # Little_Endian amsua_metop-c_v2.SpcCoeff.bin is what it's supposed to be.
         # Remove the incorrect file, and install it as noACC,, then install
         # correct file under new name.
-        if "+big_endian" in spec and spec.version == Version("2.4.0_emc"):
-            remove_path = join_path(
-                os.getcwd(), "fix", "SpcCoeff", "Big_Endian", "amsua_metop-c.SpcCoeff.bin"
+        if "+big_endian" in spec and (
+            spec.version in [Version("2.4.0_emc"), Version("2.4.0.1_emc")]
+        ):
+            amc_sc_path = join_path("SpcCoeff", "Big_Endian", "amsua_metop-c.SpcCoeff.bin")
+            amc_sc_v2_path = join_path(
+                "SpcCoeff", "Little_Endian", "amsua_metop-c_v2.SpcCoeff.bin"
             )
+            # In 2.4.0_emc, the path is prefixed by 'fix/'
+            if spec.version == Version("2.4.0_emc"):
+                amc_sc_path = join_path("fix", amc_sc_path)
+                amc_sc_v2_path = join_path("fix", amc_sc_v2_path)
+
+            remove_path = join_path(os.getcwd(), amc_sc_path)
+
             fix_files.remove(remove_path)
 
             # This file is incorrect, install it as a different name.
-            install(
-                join_path("fix", "SpcCoeff", "Big_Endian", "amsua_metop-c.SpcCoeff.bin"),
-                join_path(self.prefix.fix, "amsua_metop-c.SpcCoeff.noACC.bin"),
-            )
+            install(amc_sc_path, join_path(self.prefix.fix, "amsua_metop-c.SpcCoeff.noACC.bin"))
 
             # This "Little_Endian" file is actually the correct one.
-            install(
-                join_path("fix", "SpcCoeff", "Little_Endian", "amsua_metop-c_v2.SpcCoeff.bin"),
-                join_path(self.prefix.fix, "amsua_metop-c.SpcCoeff.bin"),
-            )
+            install(amc_sc_v2_path, join_path(self.prefix.fix, "amsua_metop-c.SpcCoeff.bin"))
 
         for f in fix_files:
             install(f, self.prefix.fix)