diff --git a/crates/bevy_pbr/src/render/mesh_view_types.wgsl b/crates/bevy_pbr/src/render/mesh_view_types.wgsl
index 7db9af72f64816..ab595b9e01f9ca 100644
--- a/crates/bevy_pbr/src/render/mesh_view_types.wgsl
+++ b/crates/bevy_pbr/src/render/mesh_view_types.wgsl
@@ -95,4 +95,8 @@ struct Globals {
     // Frame count since the start of the app.
     // It wraps to zero when it reaches the maximum value of a u32.
     frame_count: u32,
+#ifdef SIXTEEN_BYTE_ALIGNMENT
+    // WebGL2 structs must be 16 byte aligned.
+    _wasm_padding: f32
+#endif
 }
diff --git a/crates/bevy_render/src/globals.rs b/crates/bevy_render/src/globals.rs
index c910e13768d851..eea40342e10464 100644
--- a/crates/bevy_render/src/globals.rs
+++ b/crates/bevy_render/src/globals.rs
@@ -41,6 +41,9 @@ pub struct GlobalsUniform {
     /// Frame count since the start of the app.
     /// It wraps to zero when it reaches the maximum value of a u32.
     frame_count: u32,
+    /// WebGL2 structs must be 16 byte aligned.
+    #[cfg(feature = "webgl")]
+    _wasm_padding: f32,
 }
 
 /// The buffer containing the [`GlobalsUniform`]
diff --git a/crates/bevy_render/src/render_resource/pipeline_cache.rs b/crates/bevy_render/src/render_resource/pipeline_cache.rs
index 48603edefe7a24..e03857e788a8e0 100644
--- a/crates/bevy_render/src/render_resource/pipeline_cache.rs
+++ b/crates/bevy_render/src/render_resource/pipeline_cache.rs
@@ -151,7 +151,10 @@ impl ShaderCache {
             Entry::Vacant(entry) => {
                 let mut shader_defs = shader_defs.to_vec();
                 #[cfg(feature = "webgl")]
-                shader_defs.push(String::from("NO_ARRAY_TEXTURES_SUPPORT"));
+                {
+                    shader_defs.push(String::from("NO_ARRAY_TEXTURES_SUPPORT"));
+                    shader_defs.push(String::from("SIXTEEN_BYTE_ALIGNMENT"));
+                }
 
                 // TODO: 3 is the value from CLUSTERED_FORWARD_STORAGE_BUFFER_COUNT declared in bevy_pbr
                 // consider exposing this in shaders in a more generally useful way, such as: