diff --git a/Modules/Core/Common/include/itkImageRegion.h b/Modules/Core/Common/include/itkImageRegion.h
index 43d24febe32..efc457ccf85 100644
--- a/Modules/Core/Common/include/itkImageRegion.h
+++ b/Modules/Core/Common/include/itkImageRegion.h
@@ -428,13 +428,6 @@ operator<<(std::ostream & os, const ImageRegion<VImageDimension> & region);
 
 namespace std
 {
-#if defined(__clang__) && defined(__apple_build_version__) && (__clang_major__ <= 10)
-#  pragma clang diagnostic push
-// Old AppleClang 10.0.0 (Xcode 10.1, newest on macOS 10.13) produced some unimportant warnings, like:
-// "warning: 'tuple_size' defined as a struct template here but previously declared as a class template"
-#  pragma clang diagnostic ignored "-Wmismatched-tags"
-#endif
-
 // NOLINTBEGIN(cert-dcl58-cpp)
 // Locally suppressed the following warning from Clang-Tidy (LLVM 17.0.1), as it appears undeserved.
 // > warning: modification of 'std' namespace can result in undefined behavior [cert-dcl58-cpp]
@@ -460,9 +453,6 @@ struct tuple_element<VTupleIndex, itk::ImageRegion<VImageDimension>>
 
 // NOLINTEND(cert-dcl58-cpp)
 
-#if defined(__clang__) && defined(__apple_build_version__) && (__clang_major__ <= 10)
-#  pragma clang diagnostic pop
-#endif
 } // namespace std
 
 #undef itkRegionOverrideMacro
diff --git a/Modules/Core/Common/include/itkMacro.h b/Modules/Core/Common/include/itkMacro.h
index f2fe5f5314e..b2631b59fc3 100644
--- a/Modules/Core/Common/include/itkMacro.h
+++ b/Modules/Core/Common/include/itkMacro.h
@@ -216,10 +216,8 @@ namespace itk
 // define a minimum __sgi version that will work.
 #  error "The SGI compiler is not supported"
 #endif
-#if defined(__APPLE__)
-#  if defined(__clang__) && (__cplusplus < 201703L)
-#    error "Apple LLVM compiling with a standard less than C++17 is not supported"
-#  endif
+#if defined(__apple_build_version__) && (__apple_build_version__ < 12000032)
+#  error "AppleClang < Xcode 12.4 is not supported"
 #elif defined(__clang__) && (__clang_major__ < 5)
 #  error "Clang < 5 is not supported"
 #endif
diff --git a/Modules/IO/ImageBase/src/itkImageIOBase.cxx b/Modules/IO/ImageBase/src/itkImageIOBase.cxx
index d652fff66f7..824ed0d5d7f 100644
--- a/Modules/IO/ImageBase/src/itkImageIOBase.cxx
+++ b/Modules/IO/ImageBase/src/itkImageIOBase.cxx
@@ -303,12 +303,7 @@ ImageIOBase::ReadBufferAsBinary(std::istream & is, void * buffer, ImageIOBase::S
 
   const std::streamsize numberOfBytesRead = is.gcount();
 
-#ifdef __APPLE_CC__
-  // fail() is broken in the Mac. It returns true when reaches eof().
-  if (numberOfBytesRead != numberOfBytesToBeRead)
-#else
   if ((numberOfBytesRead != numberOfBytesToBeRead) || is.fail())
-#endif
   {
     return false; // read failed
   }