diff --git a/iss/generator.py b/iss/generator.py
index 7c7bc3f..90a53ca 100644
--- a/iss/generator.py
+++ b/iss/generator.py
@@ -374,6 +374,18 @@ def load_error_model(mode, seed, model, fragment_length, fragment_length_sd, sto
 
     logger.info("Using %s ErrorModel" % mode)
 
+    precomputed_error_models = {
+        "hiseq": os.path.join(os.path.dirname(__file__), "profiles/HiSeq"),
+        "novaseq": os.path.join(os.path.dirname(__file__), "profiles/NovaSeq"),
+        "miseq": os.path.join(os.path.dirname(__file__), "profiles/miSeq_0.npz"),
+        "miseq-20": os.path.join(os.path.dirname(__file__), "profiles/miSeq_20.npz"),
+        "miseq-24": os.path.join(os.path.dirname(__file__), "profiles/miSeq_24.npz"),
+        "miseq-28": os.path.join(os.path.dirname(__file__), "profiles/miSeq_28.npz"),
+        "miseq-32": os.path.join(os.path.dirname(__file__), "profiles/miSeq_32.npz"),
+        "miseq-36": os.path.join(os.path.dirname(__file__), "profiles/miSeq_36.npz"),
+        "nextseq": os.path.join(os.path.dirname(__file__), "profiles/nextSeq.npz"),
+    }
+
     if fragment_length is not None and fragment_length_sd is not None:
         logger.info(
             f"Using custom fragment length {fragment_length} and default fragment length sd {fragment_length_sd}"
@@ -390,12 +402,8 @@ def load_error_model(mode, seed, model, fragment_length, fragment_length_sd, sto
         if model is None:
             logger.error("--model is required in --mode kde")
             sys.exit(1)
-        elif model.lower() == "hiseq":
-            npz = os.path.join(os.path.dirname(__file__), "profiles/HiSeq")
-        elif model.lower() == "novaseq":
-            npz = os.path.join(os.path.dirname(__file__), "profiles/NovaSeq")
-        elif model.lower() == "miseq":
-            npz = os.path.join(os.path.dirname(__file__), "profiles/MiSeq")
+        elif model in precomputed_error_models:
+            npz = precomputed_error_models[model]
         else:
             npz = model
         err_mod = kde.KDErrorModel(npz, fragment_length, fragment_length_sd, store_mutations)
diff --git a/iss/profiles/miSeq_0.npz b/iss/profiles/miSeq_0.npz
new file mode 100644
index 0000000..e8ac899
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diff --git a/iss/profiles/miSeq_20.npz b/iss/profiles/miSeq_20.npz
new file mode 100644
index 0000000..7e10cb2
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diff --git a/iss/profiles/miSeq_24.npz b/iss/profiles/miSeq_24.npz
new file mode 100644
index 0000000..1aacdb5
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diff --git a/iss/profiles/miSeq_28.npz b/iss/profiles/miSeq_28.npz
new file mode 100644
index 0000000..0075e98
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diff --git a/iss/profiles/miSeq_32.npz b/iss/profiles/miSeq_32.npz
new file mode 100644
index 0000000..1a073f6
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diff --git a/iss/profiles/miSeq_36.npz b/iss/profiles/miSeq_36.npz
new file mode 100644
index 0000000..e1639dd
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diff --git a/iss/profiles/nextSeq.npz b/iss/profiles/nextSeq.npz
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index 0000000..e4478a6
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