diff --git a/DependencyInjection/Compiler/HandlerRegistryDecorationPass.php b/DependencyInjection/Compiler/HandlerRegistryDecorationPass.php
index 432e41438..a2ca348fd 100644
--- a/DependencyInjection/Compiler/HandlerRegistryDecorationPass.php
+++ b/DependencyInjection/Compiler/HandlerRegistryDecorationPass.php
@@ -33,7 +33,8 @@ class HandlerRegistryDecorationPass implements CompilerPassInterface
 {
     public function process(ContainerBuilder $container): void
     {
-        if (!$container->has('fos_rest.serializer.jms_handler_registry')) {
+        // skip if JMSSerializerBundle is not installed or if JMSSerializerBundle >= 4.0
+        if (!$container->has('fos_rest.serializer.jms_handler_registry') || $container->has('jms_serializer.handler_registry.service_locator')) {
             return;
         }
 
diff --git a/DependencyInjection/Compiler/JMSHandlersPass.php b/DependencyInjection/Compiler/JMSHandlersPass.php
index 77bf8eafb..7e447ab23 100644
--- a/DependencyInjection/Compiler/JMSHandlersPass.php
+++ b/DependencyInjection/Compiler/JMSHandlersPass.php
@@ -27,8 +27,11 @@ final class JMSHandlersPass implements CompilerPassInterface
     public function process(ContainerBuilder $container): void
     {
         if ($container->has('jms_serializer.handler_registry')) {
-            // the public alias prevents the handler registry definition from being removed
-            $container->setAlias('fos_rest.serializer.jms_handler_registry', new Alias('jms_serializer.handler_registry', true));
+            // perform the aliasing only when jms-serializer-bundle < 4.0
+            if (!$container->has('jms_serializer.handler_registry.service_locator')) {
+                // the public alias prevents the handler registry definition from being removed
+                $container->setAlias('fos_rest.serializer.jms_handler_registry', new Alias('jms_serializer.handler_registry', true));
+            }
 
             return;
         }
diff --git a/Tests/Functional/DependencyInjectionTest.php b/Tests/Functional/DependencyInjectionTest.php
index f84bbb094..a7b435852 100644
--- a/Tests/Functional/DependencyInjectionTest.php
+++ b/Tests/Functional/DependencyInjectionTest.php
@@ -16,6 +16,7 @@
 use FOS\RestBundle\Serializer\JMSHandlerRegistryV2;
 use FOS\RestBundle\Serializer\Normalizer\FormErrorHandler;
 use JMS\Serializer\Visitor\SerializationVisitorInterface;
+use JMS\SerializerBundle\Debug\TraceableHandlerRegistry;
 use JMS\SerializerBundle\JMSSerializerBundle;
 use Symfony\Bundle\FrameworkBundle\FrameworkBundle;
 use Symfony\Bundle\FrameworkBundle\Test\KernelTestCase;
@@ -33,6 +34,10 @@ public function testSerializerRelatedServicesAreNotRemovedWhenJmsSerializerBundl
 
         $this->assertInstanceOf(FormErrorHandler::class, $container->get('test.jms_serializer.form_error_handler'));
 
+        if (class_exists(TraceableHandlerRegistry::class)) {
+            $this->markTestIncomplete('Starting from jms/serializer-bundle 4.0 the handler registry is not decorated anymore');
+        }
+
         $this->assertInstanceOf(
             interface_exists(SerializationVisitorInterface::class) ? JMSHandlerRegistryV2::class : JMSHandlerRegistry::class,
             $container->get('test.jms_serializer.handler_registry')
diff --git a/composer.json b/composer.json
index 5b38e94e5..fe291dec4 100644
--- a/composer.json
+++ b/composer.json
@@ -57,7 +57,7 @@
         "symfony/browser-kit": "^4.4|^5.0",
         "symfony/expression-language": "^4.4|^5.0",
         "symfony/css-selector": "^4.4|^5.0",
-        "jms/serializer-bundle": "^2.4.3|^3.0.1",
+        "jms/serializer-bundle": "^2.4.3|^3.0.1|^4.0",
         "jms/serializer": "^1.13|^2.0|^3.0",
         "psr/http-message": "^1.0",
         "friendsofphp/php-cs-fixer": "^3.0"