This is a Python interface to libfuse (https://github.com/libfuse/libfuse).
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The API is described in README.new_fusepy_api.rst. It's an informative description, not a reference. Apart from that, see the examples and the actual code.
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Project home page is https://github.com/libfuse/python-fuse