diff --git a/packages/calcite-components/src/components/select/select.e2e.ts b/packages/calcite-components/src/components/select/select.e2e.ts
index f4a3c0a956b..f276ba659c3 100644
--- a/packages/calcite-components/src/components/select/select.e2e.ts
+++ b/packages/calcite-components/src/components/select/select.e2e.ts
@@ -14,7 +14,7 @@ import {
   themed,
 } from "../../tests/commonTests";
 import { html } from "../../../support/formatting";
-import { findAll } from "../../tests/utils/puppeteer";
+import { findAll, newProgrammaticE2EPage } from "../../tests/utils/puppeteer";
 import { CSS } from "./resources";
 import type { Select } from "./select";
 
@@ -422,6 +422,25 @@ describe("calcite-select", () => {
     await assertSelectedOption(page, await page.find("calcite-option[value='']"));
   });
 
+  it("does not throw when added and removed multiple times and a row", async () => {
+    const runTest = async () => {
+      async function addAndRemoveSelect(page: E2EPage): Promise<void> {
+        await page.evaluate(async () => {
+          const select = document.createElement("calcite-select");
+          document.body.append(select);
+          select.remove();
+        });
+        await page.waitForChanges();
+      }
+
+      const page = await newProgrammaticE2EPage();
+      await addAndRemoveSelect(page);
+      await addAndRemoveSelect(page);
+    };
+
+    await expect(runTest()).resolves.toBeUndefined();
+  });
+
   describe("is form-associated", () => {
     formAssociated(
       html`
diff --git a/packages/calcite-components/src/components/select/select.tsx b/packages/calcite-components/src/components/select/select.tsx
index 1f76ae4f986..3f6f03220b8 100644
--- a/packages/calcite-components/src/components/select/select.tsx
+++ b/packages/calcite-components/src/components/select/select.tsx
@@ -232,7 +232,7 @@ export class Select
 
     this.populateInternalSelect();
 
-    const selected = this.selectEl.selectedOptions[0];
+    const selected = this.selectEl?.selectedOptions[0];
     this.selectFromNativeOption(selected);
     afterConnectDefaultValueSet(this, this.selectedOption?.value ?? "");
   }