diff --git a/packages/calcite-components/src/components/input-time-zone/input-time-zone.e2e.ts b/packages/calcite-components/src/components/input-time-zone/input-time-zone.e2e.ts
index 3a4ee9af497..38831b0757d 100644
--- a/packages/calcite-components/src/components/input-time-zone/input-time-zone.e2e.ts
+++ b/packages/calcite-components/src/components/input-time-zone/input-time-zone.e2e.ts
@@ -367,9 +367,7 @@ describe("calcite-input-time-zone", () => {
 
         const timeZoneItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item[selected]");
 
-        expect(await timeZoneItem.getProperty("textLabel")).toMatch(
-          toUserFriendlyName(getCity(testTimeZoneItems[1].name)),
-        );
+        expect(await timeZoneItem.getProperty("textLabel")).toBe("Phoenix, United States");
       });
 
       it("ignores invalid values", async () => {
@@ -386,9 +384,7 @@ describe("calcite-input-time-zone", () => {
 
         const timeZoneItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item[selected]");
 
-        expect(await timeZoneItem.getProperty("textLabel")).toMatch(
-          toUserFriendlyName(getCity(testTimeZoneItems[0].name)),
-        );
+        expect(await timeZoneItem.getProperty("textLabel")).toBe("Mexico City, Mexico");
       });
 
       it("properly sets region label when setting value programmatically", async () => {
@@ -407,7 +403,7 @@ describe("calcite-input-time-zone", () => {
 
         const timeZoneItem = await page.find("calcite-input-time-zone >>> calcite-combobox-item[selected]");
 
-        expect(await timeZoneItem.getProperty("textLabel")).toMatch(toUserFriendlyName(getCity(region)));
+        expect(await timeZoneItem.getProperty("textLabel")).toBe("New York, United States");
       });
 
       it("maps deprecated time zones to aliases", async () => {
diff --git a/packages/calcite-components/src/components/input-time-zone/input-time-zone.tsx b/packages/calcite-components/src/components/input-time-zone/input-time-zone.tsx
index 24d6b30f330..f8ecec0b30f 100644
--- a/packages/calcite-components/src/components/input-time-zone/input-time-zone.tsx
+++ b/packages/calcite-components/src/components/input-time-zone/input-time-zone.tsx
@@ -304,7 +304,6 @@ export class InputTimeZone
   }
 
   loaded(): void {
-    this.overrideSelectedLabelForRegion(this.open);
     this.openChanged();
   }
 
@@ -357,11 +356,6 @@ export class InputTimeZone
 
     this._value = normalized;
     this.selectedTimeZoneItem = timeZoneItem;
-
-    if (normalized !== value) {
-      await this.updateComplete;
-      this.overrideSelectedLabelForRegion(this.open);
-    }
   }
 
   onLabelClick(): void {
@@ -378,28 +372,23 @@ export class InputTimeZone
    * @param open
    * @private
    */
-  private overrideSelectedLabelForRegion(open: boolean): void {
+  private overrideSelectedLabelForRegion(): void {
     if (this.mode !== "region" || !this.selectedTimeZoneItem) {
       return;
     }
 
-    const { label, metadata } = this.selectedTimeZoneItem;
-
-    this.comboboxEl.selectedItems[0].textLabel =
-      !metadata.country || open
-        ? label
-        : getSelectedRegionTimeZoneLabel(label, metadata.country, this.messages);
+    this.comboboxEl.selectedItems[0].textLabel = this.getItemLabel(this.selectedTimeZoneItem);
   }
 
   private onComboboxBeforeClose(event: CustomEvent): void {
     event.stopPropagation();
-    this.overrideSelectedLabelForRegion(false);
+    this.overrideSelectedLabelForRegion();
     this.calciteInputTimeZoneBeforeClose.emit();
   }
 
   private onComboboxBeforeOpen(event: CustomEvent): void {
     event.stopPropagation();
-    this.overrideSelectedLabelForRegion(true);
+    this.overrideSelectedLabelForRegion();
     this.calciteInputTimeZoneBeforeOpen.emit();
   }
 
@@ -486,6 +475,14 @@ export class InputTimeZone
     return value ? this.normalizer(value) : value;
   }
 
+  private getItemLabel(item: TimeZoneItem): string {
+    const selected = this.selectedTimeZoneItem === item;
+    const { label, metadata } = item;
+    return !this.open && item.metadata.country && selected
+      ? getSelectedRegionTimeZoneLabel(label, metadata.country, this.messages)
+      : label;
+  }
+
   //#endregion
 
   //#region Rendering
@@ -556,7 +553,7 @@ export class InputTimeZone
         {items.map((item) => {
           const selected = this.selectedTimeZoneItem === item;
           const { label, metadata, value } = item;
-
+          const textLabel = this.getItemLabel(item);
           return (
             <calcite-combobox-item
               data-label={label}
@@ -564,7 +561,7 @@ export class InputTimeZone
               key={label}
               metadata={metadata}
               selected={selected}
-              textLabel={label}
+              textLabel={textLabel}
               value={value}
             >
               <span class={CSS.offset} slot="content-end">