chloroketone.html

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<!-- Page Title: Chloroketone -->
<h2>Introduction</h2>
<p>
    These scripts show the binding of a suicide substrate analog,
    tosyl-L-phenylalanine chloromethyl ketone (TPCK) to chymotrypsin. In the
    active site, His57 becomes covalently modified when the enzyme attempts to
    carry out its catalytic cycle on the sucide substrate. (Based on 2gmt.pdb,
    Kreutter et al. (1994) Biochemistry <strong>33</strong>: 13792-13800)
</p>
<br>

<h2>TPCK</h2>
<p>
    Here is a <span style="color:green;"> chloroketone suicide substrate</span>
    bound to chymotrypsin.
</p>
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<br>

<h2>Active Site</h2>
<p>
    It makes a covalent bond to the active site, His57
    (<span style="color:gold;">YELLOW</span>).
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