diff --git a/src/Microsoft.Identity.Web.TokenAcquisition/TokenAcquisition.cs b/src/Microsoft.Identity.Web.TokenAcquisition/TokenAcquisition.cs
index 71c27e424..3fb225015 100644
--- a/src/Microsoft.Identity.Web.TokenAcquisition/TokenAcquisition.cs
+++ b/src/Microsoft.Identity.Web.TokenAcquisition/TokenAcquisition.cs
@@ -196,9 +196,16 @@ public async Task<AcquireTokenResult> AddAccountToCacheFromAuthorizationCodeAsyn
             }
         }
 
+
+        /// <summary>
+        /// Allows creation of confidential client applications targeting regional and global authorities
+        /// when supporting managed identities.
+        /// </summary>
+        /// <param name="mergedOptions">Merged configuration options</param>
+        /// <returns>Concatenated string of authority, cliend id and azure region</returns>
         private static string GetApplicationKey(MergedOptions mergedOptions)
         {
-            return mergedOptions.Instance! + mergedOptions.ClientId;
+            return DefaultTokenAcquirerFactoryImplementation.GetKey(mergedOptions.Authority, mergedOptions.ClientId, mergedOptions.AzureRegion);
         }
 
         /// <summary>
diff --git a/tests/Microsoft.Identity.Web.Test/TokenAcquisitionAuthorityTests.cs b/tests/Microsoft.Identity.Web.Test/TokenAcquisitionAuthorityTests.cs
index 3c3204349..8f98b093e 100644
--- a/tests/Microsoft.Identity.Web.Test/TokenAcquisitionAuthorityTests.cs
+++ b/tests/Microsoft.Identity.Web.Test/TokenAcquisitionAuthorityTests.cs
@@ -177,6 +177,41 @@ public async Task VerifyCorrectRedirectUriAsync(
             }
         }
 
+        [Fact]
+        public async Task VerifyDifferentRegionsDifferentApp()
+        {
+            _microsoftIdentityOptionsMonitor = new TestOptionsMonitor<MicrosoftIdentityOptions>(new MicrosoftIdentityOptions
+            {
+                Authority = TC.AuthorityCommonTenant,
+                ClientId = TC.ConfidentialClientId,
+                CallbackPath = string.Empty,
+            });
+
+            _applicationOptionsMonitor = new TestOptionsMonitor<ConfidentialClientApplicationOptions>(new ConfidentialClientApplicationOptions
+            {
+                Instance = TC.AadInstance,
+                RedirectUri = "http://localhost:1729/",
+                ClientSecret = TC.ClientSecret,
+            });
+
+            BuildTheRequiredServices();
+            MergedOptions mergedOptions = _provider.GetRequiredService<IMergedOptionsStore>().Get(OpenIdConnectDefaults.AuthenticationScheme);
+            MergedOptions.UpdateMergedOptionsFromMicrosoftIdentityOptions(_microsoftIdentityOptionsMonitor.Get(OpenIdConnectDefaults.AuthenticationScheme), mergedOptions);
+            MergedOptions.UpdateMergedOptionsFromConfidentialClientApplicationOptions(_applicationOptionsMonitor.Get(OpenIdConnectDefaults.AuthenticationScheme), mergedOptions);
+
+            InitializeTokenAcquisitionObjects();
+
+            mergedOptions.AzureRegion = "UKEast";
+
+            IConfidentialClientApplication appEast = await _tokenAcquisition.GetOrBuildConfidentialClientApplicationAsync(mergedOptions);
+
+            mergedOptions.AzureRegion = "UKWest";
+
+            IConfidentialClientApplication appWest = await _tokenAcquisition.GetOrBuildConfidentialClientApplicationAsync(mergedOptions);
+
+            Assert.NotSame(appEast, appWest);
+        }
+
         [Theory]
         [InlineData(true)]
         [InlineData(false)]