diff --git a/sdk/core/azure-core/CHANGELOG.md b/sdk/core/azure-core/CHANGELOG.md
index 7e1d570efdd8..c6d82e9509f5 100644
--- a/sdk/core/azure-core/CHANGELOG.md
+++ b/sdk/core/azure-core/CHANGELOG.md
@@ -1,6 +1,6 @@
 # Release History
 
-## 1.21.2 (Unreleased)
+## 1.22.0 (Unreleased)
 
 ### Features Added
 
@@ -12,6 +12,8 @@
 
 ### Other Changes
 
+- Python 2.7 is no longer supported. Please use Python version 3.6 or later.
+
 ## 1.21.1 (2021-12-06)
 
 ### Other Changes
diff --git a/sdk/core/azure-core/README.md b/sdk/core/azure-core/README.md
index 6b3eb96986f5..14b21daf3dfd 100644
--- a/sdk/core/azure-core/README.md
+++ b/sdk/core/azure-core/README.md
@@ -10,7 +10,7 @@ If you are a client library developer, please reference [client library develope
 
 ## _Disclaimer_
 
-_Azure SDK Python packages support for Python 2.7 is ending 01 January 2022. For more information and questions, please refer to <https://github.com/Azure/azure-sdk-for-python/issues/20691>_
+_Azure SDK Python packages support for Python 2.7 has ended 01 January 2022. For more information and questions, please refer to <https://github.com/Azure/azure-sdk-for-python/issues/20691>_
 
 ## Getting started
 
diff --git a/sdk/core/azure-core/azure/core/_version.py b/sdk/core/azure-core/azure/core/_version.py
index 94a9dea460cb..5c714d545a88 100644
--- a/sdk/core/azure-core/azure/core/_version.py
+++ b/sdk/core/azure-core/azure/core/_version.py
@@ -9,4 +9,4 @@
 # regenerated.
 # --------------------------------------------------------------------------
 
-VERSION = "1.21.2"
+VERSION = "1.22.0"
diff --git a/sdk/core/azure-core/dev_requirements.txt b/sdk/core/azure-core/dev_requirements.txt
index 6297f8880d39..4f9c87a9e464 100644
--- a/sdk/core/azure-core/dev_requirements.txt
+++ b/sdk/core/azure-core/dev_requirements.txt
@@ -1,10 +1,9 @@
-trio; python_version >= '3.5'
-aiohttp>=3.0; python_version >= '3.5'
+trio
+aiohttp>=3.0
 typing_extensions>=3.7.2
 opencensus>=0.6.0
 opencensus-ext-azure
 opencensus-ext-threading
-mock; python_version < '3.3'
 -e ../../../tools/azure-sdk-tools
 -e ../../../tools/azure-devtools
 -e tests/testserver_tests/coretestserver
\ No newline at end of file
diff --git a/sdk/core/azure-core/samples/conftest.py b/sdk/core/azure-core/samples/conftest.py
deleted file mode 100644
index 6d453aed7c4c..000000000000
--- a/sdk/core/azure-core/samples/conftest.py
+++ /dev/null
@@ -1,32 +0,0 @@
-# --------------------------------------------------------------------------
-#
-# Copyright (c) Microsoft Corporation. All rights reserved.
-#
-# The MIT License (MIT)
-#
-# Permission is hereby granted, free of charge, to any person obtaining a copy
-# of this software and associated documentation files (the ""Software""), to
-# deal in the Software without restriction, including without limitation the
-# rights to use, copy, modify, merge, publish, distribute, sublicense, and/or
-# sell copies of the Software, and to permit persons to whom the Software is
-# furnished to do so, subject to the following conditions:
-#
-# The above copyright notice and this permission notice shall be included in
-# all copies or substantial portions of the Software.
-#
-# THE SOFTWARE IS PROVIDED *AS IS*, WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
-# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
-# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
-# AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
-# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
-# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS
-# IN THE SOFTWARE.
-#
-# --------------------------------------------------------------------------
-import sys
-
-# Ignore collection of async tests for Python 2
-collect_ignore = []
-if sys.version_info < (3, 5):
-    collect_ignore.append("test_example_async.py")
-
diff --git a/sdk/core/azure-core/setup.cfg b/sdk/core/azure-core/setup.cfg
deleted file mode 100644
index 3c6e79cf31da..000000000000
--- a/sdk/core/azure-core/setup.cfg
+++ /dev/null
@@ -1,2 +0,0 @@
-[bdist_wheel]
-universal=1
diff --git a/sdk/core/azure-core/setup.py b/sdk/core/azure-core/setup.py
index e401a66a5f94..50c20bca50b2 100644
--- a/sdk/core/azure-core/setup.py
+++ b/sdk/core/azure-core/setup.py
@@ -47,8 +47,7 @@
     classifiers=[
         "Development Status :: 5 - Production/Stable",
         'Programming Language :: Python',
-        'Programming Language :: Python :: 2',
-        'Programming Language :: Python :: 2.7',
+        "Programming Language :: Python :: 3 :: Only",
         'Programming Language :: Python :: 3',
         'Programming Language :: Python :: 3.6',
         'Programming Language :: Python :: 3.7',
@@ -66,13 +65,9 @@
     package_data={
         'pytyped': ['py.typed'],
     },
+    python_requires=">=3.6",
     install_requires=[
         'requests>=2.18.4',
         'six>=1.11.0',
     ],
-    extras_require={
-        ":python_version<'3.0'": ['azure-nspkg'],
-        ":python_version<'3.4'": ['enum34>=1.0.4'],
-        ":python_version<'3.5'": ['typing'],
-    }
 )
diff --git a/sdk/core/azure-core/tests/async_tests/conftest.py b/sdk/core/azure-core/tests/async_tests/conftest.py
index 17c93009a373..c9bb6be411d4 100644
--- a/sdk/core/azure-core/tests/async_tests/conftest.py
+++ b/sdk/core/azure-core/tests/async_tests/conftest.py
@@ -82,19 +82,6 @@ def testserver():
     yield
     terminate_testserver(server)
 
-
-# Ignore collection of async tests for Python 2
-collect_ignore_glob = []
-if sys.version_info < (3, 5):
-    collect_ignore_glob.append("*_async.py")
-
 @pytest.fixture
 def client(port):
     return AsyncTestRestClient(port)
-
-import sys
-
-# Ignore collection of async tests for Python 2
-collect_ignore = []
-if sys.version_info < (3, 5):
-    collect_ignore.append("async_tests")
diff --git a/sdk/core/azure-core/tests/conftest.py b/sdk/core/azure-core/tests/conftest.py
index 99273ebe1806..d8c65639bbb5 100644
--- a/sdk/core/azure-core/tests/conftest.py
+++ b/sdk/core/azure-core/tests/conftest.py
@@ -34,12 +34,6 @@
 from rest_client import TestRestClient
 import sys
 
-# Ignore collection of async tests for Python 2
-collect_ignore = []
-if sys.version_info < (3, 5):
-    collect_ignore.append("async_tests")
-
-
 # If opencensus is loadable while doing these tests, register an empty tracer to avoid this:
 # https://github.com/census-instrumentation/opencensus-python/issues/442
 try:
diff --git a/sdk/core/ci.yml b/sdk/core/ci.yml
index 77ac049ef0f1..3f029f1d8a48 100644
--- a/sdk/core/ci.yml
+++ b/sdk/core/ci.yml
@@ -31,11 +31,6 @@ extends:
   template: ../../eng/pipelines/templates/stages/archetype-sdk-client.yml
   parameters:
     ServiceDirectory: core
-    MatrixConfigs:
-      - Name: core_ci_matrix
-        Path: sdk/core/platform-matrix.json
-        Selection: sparse
-        GenerateVMJobs: true
     Artifacts:
     - name: azure-core
       safeName: azurecore
diff --git a/sdk/core/platform-matrix.json b/sdk/core/platform-matrix.json
deleted file mode 100644
index 8eedc22dc0be..000000000000
--- a/sdk/core/platform-matrix.json
+++ /dev/null
@@ -1,18 +0,0 @@
-{
-    "matrix": {
-      "$IMPORT": "eng/pipelines/templates/stages/platform-matrix.json"
-    },
-    "include": [
-        {
-            "Config": {
-                "Ubuntu2004_py27": {
-                    "OSVmImage": "MMSUbuntu20.04",
-                    "Pool": "azsdk-pool-mms-ubuntu-2004-general",
-                    "PythonVersion": "2.7",
-                    "CoverageArg": "--disablecov",
-                    "TestSamples": "false"
-                }
-            }
-        }   
-    ]
-}
diff --git a/sdk/identity/azure-identity/setup.cfg b/sdk/identity/azure-identity/setup.cfg
deleted file mode 100644
index 3c6e79cf31da..000000000000
--- a/sdk/identity/azure-identity/setup.cfg
+++ /dev/null
@@ -1,2 +0,0 @@
-[bdist_wheel]
-universal=1